The MRSEC is managed by an executive committee consisting of Juan de Pablo (director), Tom Kuech (IRG 1), Izabela Szlufarska (IRG 1), Bob Hamers (IRG 2), Paul Evans (IRG 2), Nick Abbott (IRG 3), Doug Weibel (Education and Outreach), Greta Petersen (Education and Outreach), and Jon McCarthy (Facilities). The research is carried out by interdisciplinary research groups (IRGs) on a rolling horizon basis and smaller seed groups on a limited-term (2 - 3 year) basis.

IRG 1 focuses on the science and technology of semiconductor nanomembranes so thin that the thinness determines the structure and topography, and creates distinct electronic, mechanical, chemical and optical properties.

IRG 2 is dedicated to discovering and exploiting the dynamics of atoms and molecules at interfaces between organic optoelectronic materials and inorganic systems including oxides and nanocarbon.

IRG 3 focuses on the design, synthesis, and processing of three-dimensional substrates with controlled topography on the 1 - 100nm scale and their use as interfaces to biology.

Interdisciplinary Education Group efforts impact the wider scientific community and the public.

Research Facilities supported by the MRSEC are available for use by the national materials science community.